With her CC trinkts and district, I think that's something like +20 or 25% Protection & Health, bonuses to her Blight resistance and skill + debuff, +12 Accuracy (Quirk + District) and +15% damage ranged & melee. I'd personally want her to use her CC trinket set and have 4 quirks locked in: Luminous, Hard Skinned, Corvids Eye (+8 ACC), & Prismatic Force. I wonder about how effective a very particular Shieldbreaker could work in the comp. I've also seen Filthy Robot use the Crusader in place of Jester for the death's door debuff removal and stress control + stunning in rank 2, freeing Plague Doctor up for rank 3 (double up on accuracy trinkets for leper (Focus Ring + his +8 Acc + 3% Crit special uncomon). Plague Doctor is effectively set up for Position 2, but has his Battle Medicine skill up and ready for when a shift is needed. Battle Ballad & Inspiring Tune are musts. Jester uses Dirk Stab and Slice Off, swapping between slots 4, 3 and 2 as needed.
Vestal is set up primarily for position 4, but can work in position 2 in a pinch as one of the big selling points for her heals beyond reliability is that she has Divine Comfort which works in pos 2. I think the favorite one I've really looked at has been the general model as mentioned by Skinny Pete, with some adjustments: Jester + Vestal + Plague Doctor + Leper.
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